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Q " # T # S $ Quality Assurance
in Hemostasis
AACC understands that your job
demands results as quickly as possible
and your time for career enrichment is limited.
o t into this strained schedule is
holding three Quick Take webinars in
ugust. ll webinars take place at lunch
time T. ecordings of
missed sessions will be provided. You get
all three webinars for the price of one and
. T credits.
pert eorge ritsma author of ress Quick Guide to Hematology Testing,
understands the importance of valid
coagulation testing. ritsma will present
three webinars discussing Q and Q issues
that relate specically to hemostasis.
Over the course of three webinars,
to be held August 7, 14, and 21, learn
X
ow to develop a rilldwards curve to establish the partial
thromboplastin time TT unfractionated heparin therapeutic range
X
ow to determine TT sensitivity to factor and deciency
X
Specimen management for coagulation and platelet aggregometry
X
How to employ local calibration for prothrombin time/international
normalied ratio T/ monitoring of warfarin therapy
EXPERT: George Fritsma, MS, MLS
ssociate rofessor and consultant to the epartment of !aboratory
edicine "niversity of labama at irmingham proprietor of
The ritsma actor your nteractive Hemostasis esource
www.fritsmafactor.com and coeditor of Hematology, Clinical
Principles and Applications lsevier ress
REGISTER TODAY!
www.aacc.org/QuickTakes14
Available Now from AACC Press!
Principles of Forensic
Toxicology, 4th Edition
Edited by Barry Levine
2013, 550 pages, softcover
ISBN 9781594251580
Product # 8288
Price only $99; AACC Member $79
This fourth edition of the classic, best-selling textbook—ideal for the
classroom and the reference shelf—includes a new section on “special
topics” in forensic toxicology and updated chapters on drug testing,
methods validation, alcohol, GHB, and metals. Since the publication of the
first edition in 1999, Principles of Forensic Toxicologyy has been used extensively
for teaching students taking a one-semester course in forensic toxicology. It has
also proven to be an invaluable reference for laboratorians.
The first section provides an introduction to postmortem forensic toxicology,
human performance forensic toxicology, forensic drug testing, and
pharmacokinetics and pharmacodynamics. Additions to this section of the
fourth edition include chapters on pain management and performanceenhanced drug testing.
HOW TO ORDER
ONLINE:
http://www.aacc.org
and click on the
AACC Store link
CALL:
The second section is devoted to analytical principles, including both theory
and applications. Methodologies covered include specimen preparation,
spectrophotometry, chromatography, immunoassay, mass spectrometry,
and methods validation.
(800) 892-1400
or (202) 857-0717
FAX:
(202) 887-5093
The third section covers commonly encountered analytes, including
alcohol, benzodiazepines, GHB, miscellaneous central nervous system
depressants,opioids,cocaine,cannabis,amphetamines/sympathomimetic
amines, hallucinogens, anticonvulsants, antiarrhythmics, antidepressants,
antihistamines, neuroleptics, nonnarcotic analgesics, carbon monoxide/
cyanide, inhalants, and metals.
The newly added fourth section includes chapters on in vitro
stability of drugs, postmortem redistribution, postmortem chemistry,
pharmacogenomics, hair, and meconium.
www.aacc.org
MAIL:
AACC Customer Service
1850 K Street NW, Suite 625
Washington, DC 20006
Available Now from AACC Press!
Quick Guide to
Immunoassay Interference
By Pradip Datta, Adetoun A. Ejilemele,
and John R. Petersen
2013, 75 pages, spiral binding
ISBN 9781594251566
Product # 8289
Price only $22; AACC Member $18
The Quick Guide to Immunoassay Interference is a valuable resource for medical
laboratory scientists and directors, physicians, and other clinical support personnel
to identify how laboratory immunoassay results may be affected by different
types of interference. The Guide’s pocket size provides immediate access about
what to watch for and how to correct such aberrant results, which are now ever
dependent on clinical laboratory results, and maintain the integrity of patient
care.
Starting from the basics of both immunoassays and assay interference,
the Guide presents various sources of assay interference: cross-reactivity,
prozone effects, heterophilic antibodies, endogenous serum components,
system components, and analyte heterogeneity. The Guide also includes the
various sources of preanalytical interference and is intended to be used as
a reference for the diagnostics and pharmaceutical industries with regard
to choosing an assay design to minimize interferences and to product
support specialists so they can respond to reports of erroneous results
from their customers.
The Guide can be used to assist physicians, pharmacists, pathologists,
physician assistants, and medical fellows, residents, and students
in understanding not only how to detect erroneous immunoassay
results before making clinical decisions based on them but how such
interference can be resolved and correct results may be obtained. The
information contained in this Quick Guide also clarifies laboratory assay
utilization to help predict, diagnose, and monitor therapy for clinical
conditions and disease.
www.aacc.org
HOW TO ORDER
ONLINE:
http://www.aacc.org
and click on the
AACC Store link
CALL:
(800) 892-1400
or (202) 857-0717
FAX:
(202) 887-5093
MAIL:
AACC Customer Service
1850 K Street NW, Suite 625
Washington, DC 20006
Get informed on the principles and applications of good statistical
QC practices with a new online certificate program from
Practical Approaches to
Quality Control
in the Clinical Laboratory
IN SEVEN COURSES, LEARN HOW TO:
X
apply the appropriate statistical QC practices to monitor the performance of your test procedures
X
select proper materials and establish reliable target and control values
X
implement suitable QC rules to assess your test performance
X
use the appropriate frequency to measure QC samples
X
respond to a QC rules failure
X
establish protocols to review QC data
X
interpret proficiency testing results for procedure improvement
Each on-demand course can be accessed online from any computer. The program features lectures with
an esteemed faculty, published material and quizzes, plus interactive discussion boards where you can
address questions to the faculty or your peers. 10 CE credits are offered for the successful completion of
this program.
Learn more about this program’s
content and faculty at
www.aacc.org/PracticalQC
Enhance your entire laboratory with a special
offer: Enroll four or more learners into this program and get
the discounted rate for AACC members. Call AACC Customer
Service for details at 800-892-1400 or (202) 857-0717.
Clinical Chemistry
Trainee Council
Sign up with our 30-second, 1-step registration at
traineecouncil.org
Also available in Chinese, Spanish and Portuguese
Clinical Chemistry
Trainee Council
traineecouncil.org
Content includes –
t Clinical Case Studies
t Webcasts and Courses
t Question Bank
t Pearls of Laboratory Medicine
t Q&A
t Podcasts and CouncilChat
Download the
Clinical
Chemistry
app via
and
Clin
Chem
2014 CLINICAL CHEMISTRY WEBINAR SERIES
Cardiac Disease
N
ewly released guidelines are changing the lab’s role in the management of patients at risk of having
a cardiac event. Researchers continue to discover new markers or novel ways to use existing assays
to identify cardiovascular events earlier. Early diagnosis of both conditions allows
clinicians to intervene and prevent further damage, leading
to better patient outcomes.
AACC keeps laboratorians on the cusp of these new
developments with three exclusive webinars featuring
lectures, question-and-answer sessions, and research
selections with experts from the Clinical Chemistry journal.
WEBI N A RS INC LUDE:
JULY 8 The Drive to Define “Normal”: The 99th
Percentile Value of Cardiac Troponin
Fred Apple, PhD, Medical Director of Clinical Laboratories,
Clinical Chemistry, POC Testing and Clinical And Forensic
Toxicology Laboratories at Hennepin County Medical
Center, and Professor of Laboratory Medicine and
Pathology, University of Minnesota School of Medicine, Minneapolis, MN
SEPTEMBER 2
Stroke Biomarkers: Current Status, Future Promise
Robert Christenson, PhD, Professor of Pathology and of Medical and Research Technology at the
University of Maryland School of Medicine, and Director of the Clinical Chemistry, Toxicology, and Core
Laboratories and Point of Care Services at the University of Maryland Medical Center, Baltimore, MD
SEPTEMBER 9
CVD Risk Prediction: The Evolving Role of Laboratory Testing
Paul Ridker, MD, MPH, Director, Center for Cardiovascular Disease
Prevention at Brigham and Women’s Hospital and Eugene
Braunwald Professor of Medicine at Harvard Medical School,
Boston, MA
Learn from leading experts and stay informed – without
PURCHASE ALL
3 WEBINARS
AND SAVE 15%
travel expenses or time away from the office. For more
MEMBER PRICE: $455
information, individual webinar prices and to register, visit
NON-MEMBER PRICE: $575
www.aacc.org/cardiac14.
Available Now from AACC Press!
Quick Guide to
Molecular Diagnostics
By D. Hunter Best, Elaine Lyon,
Kristina A. Roberts, and Alex Valsamakis
2013, 234 pages, spiral binding
ISBN 9781594251597
Product # 7297
Price only $24; AACC Member $20
HOW TO ORDER
The Quick Guide to Molecular Diagnostics is intended for physicians,
residents/fellows, allied medical health professionals, nonmedical
professionals, and students who wish to better understand the complex
field of molecular diagnostics. The Guide is intended to be a quick,
informative reference for individuals who order molecular tests in
the fields of genetics, oncology, and infectious disease. For each of
these fields, information about common molecular diagnostic tests
is provided to assist in ordering and results interpretation. Molecular
laboratory techniques are also discussed to help readers better
understand their advantages and limitations. The pocket size
of this text offers immediate access when and where tests are
ordered. Our experience suggests that this Guide will be a useful
reference for individuals in many different fields.
ONLINE:
http://www.aacc.org
and click on the
AACC Store link
CALL:
(800) 892-1400
or (202) 857-0717
FAX:
(202) 887-5093
MAIL:
AACC Customer Service
1850 K Street NW, Suite 625
Washington, DC 20006
www.aacc.org
Clinical Chemistry
2015 Special Issue
Call for Papers
Molecular Diagnostics
A Revolution in Progress
SUBMIT NOW
Clinical Chemistry is pleased to announce a special upcoming theme issue on Molecular Diagnostics
edited by Drs. Rossa W.K. Chiu, Frank R. Cockerill, Y.M. Dennis Lo, and Carl T. Wittwer titled
“Molecular Diagnostics: A Revolution in Progress.” Clinical Chemistry, published by the American
Association for Clinical Chemistry, is the most highly cited forum for peer-reviewed, original
research in the fields of clinical chemistry and laboratory medicine.
The purpose of this issue is to highlight recent advances in molecular diagnostics that focus on
either: (1) clinical applications that use molecular diagnostics to reach novel conclusions about
disease and/or therapy; or (2) new technologies that improve high-volume needs, test turnaround
time, comprehensive analysis, or ease of use.
Clinical Chemistryy invites authors to submit original articles related to molecular diagnostics for
potential publication in this special issue. In general, manuscripts must be quantitative rather than
descriptive. Article selection will be based on the overall quality and potential impact of the manuscript.
Potential topics of interest include:
r
r
r
r
r
r
r
r
New technologies that further advance the utility of molecular diagnostics
Significant applications of molecular diagnostics that improve patient care
Sample-to-answer platforms that can be used at the point of impact
Informatics advances to analyze genomes, exomes, transcriptomes, epigenomes, or microbiomes
Generic technologies that depend less on proprietary instruments and reagents
Novel massively parallel sequencing approaches
Methods and applications of cell-free nucleic acid analysis
Guidelines for using specific molecular diagnostic techniques
Be a part of this exciting issue!
Submissions must be received through our online submission system at submit.clinchem.org. We welcome
submissions after June 2014, but cannot guarantee the inclusion of late submissions for the Special Issue. Your
cover letter should express your interest in submitting your paper for consideration for the Molecular Diagnostics
theme issue. Journal guidelines for submission apply as described in the Information for Authors on the
submission website.
American Association for Clinical Chemistry
aacc.org
presents:
Patient Safety Essentials
for Laboratory Professionals Certificate Program
New online certificate program from AACC, with strategies and tools
to implement patient safety measures.
šAn extensive program with a laboratory focus, taught by experts.
šFaculty with experience furthering improvements for patient
safety in their labs and communities.
šHighlights work culture elements that positively impact safety
initiatives, risk management and quality improvement tools, error
detection methods, and addressing personnel issues.
For information on content, special pricing for
AACC members, and registration, please visit
www.aacc.org/cert_prog
October
be
er 9-10
0
2014
St. Louis, MO
MASS SPECTROMETRY
IN
THE
CLINICAL
LAB:
Best Practices and Current Applications
Join AACC for an information-packed conference focusing on current
applications of mass spectrometry-based testing in the clinical lab.
—the value
Our expert faculty will be on hand to show users—and potential users—the
of mass spec tools in managing patient health, in addition to examining some of the
applications already used in the clinical lab, including pain management,
t, pediatric
testing, sex hormones, immunosuppressants, and vitamin D analysis.
Meet us in St. Louis this October to gain expertise and learn how to implement
ement o
orr
optimize mass spectrometry resources.
REGISTER TODAY!
www.aacc.org/MassSpec14
DIVISION DIRECTOR OF CLINICAL CHEMISTRY
HENRY FORD HEALTH SYSTEM
The Department of Pathology at the Henry Ford Hospital (HFH) and Medical Group invites applications for a full-time clinical scientist as the
director of the division of Clinical Chemistry Laboratories. The position entails responsibilities in directing the provision of clinical chemistry and
immunochemistry testing throughout the Pathology product-line of the Henry Ford Health System as well as the teaching of residents, fellows and
medical technology students.
The candidate must hold a PhD degree, and be certified by the American Board of Clinical Chemistry. The successful candidate will have a strong
post-graduate background of at least three years in clinical and laboratory chemistry and immunochemistry in a university or large hospital/health
system setting. In addition, the candidate should have a record progressively increasing managerial responsibility in the laboratory. The latter entails
substantive activities in evaluation and implementation of testing and related quality assurance activities, in accordance with federal, state and local
regulatory requirements.
HFH is an 811 bed, tertiary care facility in Detroit, MI, and the Pathology Department is the 12th largest hospital based laboratory in the country. The
chemistry and other laboratories provide services to a level 1 trauma center, solid organ/stem cell transplant and comprehensive oncology programs,
and 160 bed ICUs dedicated to surgical, medical, neurologic, neonatal and oncologic critical care. The HFH Pathology Department also serves as a
core reference laboratory and as the source of expertise and oversight for the technical, regulatory and interpretive aspects of chemistry and other
clinical laboratory testing in the Health System. This includes 3 other acute care hospitals, 1 psychiatric hospital and a network of 30 System
“outpatient clinics in Southeast Michigan.
HFH serves as one of the area’s predominant health care teaching institutions. As part of this, HFH Pathology directly supports a training program of
16 pathology residents in anatomic and clinical pathology, as well as internships for Medical Technology students from the two major training programs
in the State. Lastly, educational support in laboratory science is provided to other HFH medical specialty's residency and fellowship programs.
The Pathology product-line is an ISO 15189 accredited system of laboratories overseen by a pathologist vice-president and chair. Physicians and
Clinical Scientists are members of the Henry Ford Medical Group, one of the nation’s largest and oldest group practices composed of over 1,200
physicians in 40 specialties. Medical school academic appointments are available with several primary affiliates including Wayne State University
School of Medicine.
Interested applicants should submit curriculum vitae, a statement describing previous accomplishments and future direction and the names of three
references to:
John L. Carey, MD
Vice Chairman, Pathology and Laboratory Medicine
Henry Ford Hospital and Medical Group
2799 W. Grand Blvd.
Detroit, MI 48202-2689
(313) 916-1533
jcarey1@hfhs.org
Clinical Chemistry
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16A
Available Now from AACC Press!
Quick Guide to Clinical
Chemistry, 2nd Edition
By Janelle M. Chiasera,
Robert W. Hardy, and John A. Smith
2013, 150 pages, spiral binding
ISBN 9781594251443
Product # 7293
Price only $24; AACC Member $20
The Quick Guide to Clinical Chemistry, Second Edition, is a pocket-sized
reference intended for physicians, nurses, physician assistants, nurse
practitioners, medical technologists, pharmacists, and residents and
students in those professions. This Guide focuses on the selection
and use of chemistry laboratory tests for diagnosing and managing
emergent conditions such as poisonings, acute abdominal pain,
sepsis, and acute myocardial infarction.
The Guide’s small size allows it to be used in situations when quick
decisions must be made regarding the ordering and interpretation
of chemistry tests. The emergent clinical conditions and the
associated laboratory tests are described together for quick
reference.
HOW TO ORDER
ONLINE:
http://www.aacc.org
and click on the
AACC Store link
CALL:
(800) 892-1400
or (202) 857-0717
FAX:
Although this Guide reviews several clinical conditions, it is not
intended to be a comprehensive guide to all clinical laboratory
tests, nor is it intended to dictate what constitutes reasonable,
appropriate, or best care in a given situation. Comprehensive
references for such information currently exist. Instead, it
should be seen as it is clearly named, a “Quick Guide” to
clinical chemistry.
www.aacc.org
(202) 887-5093
MAIL:
AACC Customer Service
1850 K Street NW, Suite 625
Washington, DC 20006
NOW AVAILLABLE FROM
Editedby:UttamGarg,PhD;LaurieD.Smith,MD,PhD;andBryceA.Heese,MD
Laaborattory
to y tessting
ngg pla
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Softcoverr
Copyrightt: 2012
Pages: 25
52 pages
ISBN: 978
81594251405
TrimSize: 7 x 10
Product ID
D: 7291
Price: $61
1.00
Member Price:
P
$49.00
Contents
1.
Introduction to th
he Labo
Laboora
ratory
ryy Diagnossis of In
Inhe
h ri
he
r te
ted
Metabolic Diseasses
Uttam Garg, Laurie
i D
ie
D. Smith
Sm h, andd B
Bry
ryce A. He
ry
Heesse
2.
Amino Acid Disorders
Zhen Zhao, Van Leung-Pineda, and Den
ennis J. Dietzen
3.
Organic
g
Acid Disorders
Stanley F. Lo, Jessica A. Scott-Schwoerer, and
William J. Rhead
4.
The Urea Cycle Disorders and Hyperammonemias
Laurie D. Smith and Uttam Garg
5.
Disorders of the Carnitine Cycle and Mitochondrial
Fatty Acid Oxidation
Patricia M. Jones and Michael J. Bennett
6.
Disorders of Carbohydrate Metabolism
Angela Ferguson, Laurie D. Smith, and Uttam Garg
7.
Lysosomal Storage Disorders: Mucopolysaccharidoses
and Mucolipidoses
Andrea M. Atherton, Laurie D. Smith, Bryce A. Heese, and
Uttam Garg
8.
9.
Peroxisomal Disorders
Laurie D. Smith and Uttam Garg
10. Disorders of Purine and Pyrimidine Meetabolism
11. Laboratory Diagnosis of Serotonin and
Catecholamine Disorders
Keith Hyland
y
and Lauren A. Hyland
y
12. Creatine Deficiency Syndromes
V. Reid Sutton, William E. O’Brien, and Qin Sun
13. The Congenital Disorders of Glycosylation
Miao He, Dietrich Matern, Kimiyo M. Raymond,
and Lynne Wolfe
14. Lactic Acidemia and Mitochondrial Disorders
Devin Oglesbee and Bryce A. Heese
15. Newborn Screening
Uttam Garg, Bryce A. Heese, and Laurie D. Smith
16. Other Inherited Metabolic Diseases
Uttam Garg and Laurie D. Smith
17. Index
Lysosomal Storage Disorders: Sphingolipidoses
and Lysosomal Transport Disorders
Andrea M. Atherton, Laurie D. Smith, Bryce A. Heese,
and Uttam Garg
Order Online: www.aacc.org and click on the AACC store link or Call (800) 892-1400 / (202) 887-5093
Available Now from AACC Press!
Quick Guide to
Hematology Testing,
2nd Edition
By Vishnu Reddy, Marisa B. Marques,
and George A. Fritsma
2013, 180 pages, spiral binding
ISBN 9781594251559
Product # 8290
Price only $24; AACC Member $20
The Quick Guide to Hematology Testingg is a speedy reference for anyone who
orders, performs, or interprets hematology laboratory tests, including complete
blood counts, bone marrow aspirate and biopsies, flow cytometry, cytogenetics,
and molecular diagnosis. Clear understanding of the significance of hematology
laboratory results is critical, and awareness of the effect of confounding factors
leads to clinically sound interpretations.
The Guide’s pocket size provides immediate access at the time and place that
tests are ordered, performed, and interpreted. The text discusses benign and
malignant conditions of the three cell lineages, including anemias, leukemias,
and thrombocytopenia, emphasizing their diagnosis, treatment, and
laboratory-based treatment monitoring. Disease descriptions and assays
are adjacent so that all conditions may be correlated. The extensively
updated second edition has new sections and expands on newly described
phenotypes and genotypes of hematologic disorders and new methods,
providing a current list of cell markers and mutations.
Although the Guidee reviews clinical conditions, treatment, and laboratory
assays, it should not be used alone to make final diagnoses. Many
current references are provided for further reading. The authors’ local
experience helps make the Guidee a valuable resource for physicians,
physician assistants, nurse practitioners, nurses, pharmacists, and
medical laboratory scientists.
www.aacc.org
HOW TO ORDER
ONLINE:
http://www.aacc.org
and click on the
AACC Store link
CALL:
(800) 892-1400
or (202) 857-0717
FAX:
(202) 887-5093
MAIL:
AACC Customer Service
1850 K Street NW, Suite 625
Washington, DC 20006
Register Today!
Critical and
Point-of-Care
Testing:
Real World and Emerging
Applications for Improved
Clinical Outcomes
CPOCT 25th International Symposium
SE P TE MBER 17-20, 2014
PA R A D ISE POINT CONF EREN CE C EN TER
SA N D IEGO, CA
The 25th International Symposium examines how technological advances in point-of-care testing
and healthcare delivery trends are changing the face of clinical diagnostics and the quality of
patient care. Learn from content experts and peers as they explore the practical and promising
applications of point-of-care testing for clinical decision making. Sessions include:
•
•
•
•
•
Point-of-Care and Molecular Diagnostics
Point-of-Care and Infectious Disease
Point-of-Care Testing for Assessment of Coagulation
Point-of-Care Testing for Emergency Preparedness and Resource Limited Countries
Practical Applications of Point-of-Care Testing: Data Driven Solutions for Improved
Outcomes
The meeting promises a stimulating mix of scientific presentations, interaction with POCT experts
from around the world, introduction to new technologies from leading companies in the field,
and time to talk with colleagues in the warm, relaxed environment of Paradise Point Conference
Center in San Diego, CA, USA.
REGISTER TODAY: WWW.AACC.ORG/CPOCT14
Sponsored by the AACC CPOCT Division in cooperation with CSCC and EFLM, and under the auspices of IFCC.
The conference is supported by educational grants from Accriva Diagnostics, Alere, Instrumentation Laboratory, Medica
Corporation, Nova Biomedical Corporation, Radiometer, Roche, and Siemens Healthcare Diagnostics.
Available Now from AACC Press!
Quick Guide to
Endocrinology
By William E. Winter,
Lindsay A. L. Bazydlo, and Neil S. Harris
2013, 189 pages, spiral binding
ISBN 9781594251573
Product # 7298
Price only $28; AACC Member $23
HOW TO ORDER
The Quick Guide to Endocrinology addresses the clinical
presentation, pathophysiology, and laboratory testing required
for diagnosing common endocrinologic problems seen by the
laboratorian and clinician on a regular basis. The Guide focuses
on disturbances involving the anterior and posterior lobes of
the pituitary gland, the thyroid gland, the adrenal glands, the
parathyroid glands, the ovaries, and the testes. A future Quick
Guide will address issues relevant to diabetes mellitus.
Understanding the basic biochemistry and physiology of endocrine
systems is critically important when the laboratorian serves as a
consultant to the clinician. This Guide can help assist graduate
students, medical students, medical technologists, and laboratory
supervisors, as well as MDs and PhDs, in comprehending basic
endocrinology. Endocrine disorders are common and affect all
aspects of medicine involving psychiatrists to neurosurgeons,
and the information found in this Quick Guide will help prepare the
laboratorian to act as a consultant to all of these practitioners.
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and click on the
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BioMedical Specimen Bank
Provides various types of biological samples along with
corresponding panels of data including analycal
parameters, anthropometric variables and clinical
informaon for the diagnosc industry, assay
manufacturers and researchers.
&ŽƌŵŽƌĞŝŶĨŽƌŵĂƟŽŶƉůĞĂƐĞŐŽƚŽ
www.biomedicalspecimenbank.com
A
ƐƐĂLJĞǀĞůŽƉŵĞŶƚĂŶĚsĂůŝĚĂƟŽŶWĂŶĞůƐ
A1 Serum
A2 Urine
A1a
Normal Healthy Individuals
(sera from 48-230 men and 48-230 women – healthy
donors)
lthyy blood
b
ĂƚĂƉƌŽǀŝĚĞĚ͗ Basic anthropometric data (race, sex,
sexx, age,
a height,
weight, BMI), basic biochemistry, blood count
A2a
Normal Healthy Individuals
(urine from 48-230 men and 48-230 women – healthy blood donors)
ĂƚĂƉƌŽǀŝĚĞĚ͗Basic anthropometric data (race, sex, age, height,
weight, BMI), basic biochemistry
B
ϭď DĂƚƌŝdžīĞĐƚWĂŶĞů
od donors,
do
(12 healthy individuals, 6 men and 6 women, blood
presented
rin plasma)
pl
as serum, EDTA plasma, citrate plasma and heparin
ĂƚĂƉƌŽǀŝĚĞĚ͗ Basic anthropometric data (race, sex,
sexx, age,
a height,
weight, BMI), basic biochemistry
Ϯď &ƌĞĞnjĞͲdŚĂǁWĂŶĞů
(8 healthy individuals, 4 men and 4 women, blood donors, urine
WŚLJƐŝŽůŽŐŝĐĂůWĂŶĞůƐ
ƵŶƚŚĂǁĞĚƵƉƚŽƚŚĂǁĞĚĂŶĚĨƌŽnjĞŶϭϭƟŵĞƐͿ
ĂƚĂƉƌŽǀŝĚĞĚ͗Basic anthropometric data (race, sex, age, height,
weight, BMI), basic biochemistry
ϭĐ &ƌĞĞnjĞͲdŚĂǁWĂŶĞů
ϮĐ dĞŵƉĞƌĂƚƵƌĞ^ƚĂďŝůŝƚLJWĂŶĞůĂƚƌŽŽŵƚĞŵƉĞƌĂƚƵƌĞ
ϭŽĚLJDĂƐƐ/ŶĚĞdžWĂŶĞů
ϰ^ƵƉŝŶĞͬhƉƌŝŐŚƚWĂŶĞů
(8 healthy individuals, 4 men and 4 women, blood
sera
(8 healthy individuals, 4 men and 4 women, blood donors, urine stored
d donors,
don
&ŽƌŵŽƌĞŝŶĨŽƌŵĂƟŽŶƉůĞĂƐĞŐŽƚŽ
(96 individuals,ĂƚƌŽŽŵƚĞŵƉĞƌĂƚƵƌĞĨŽƌϬƚŽϮϰŚŽƵƌƐ͕ƌĞƐƉĞĐƟǀĞůLJͿ
4 individuals from each BMI (BMI 17-40))
17
7-4
ƵŶƚŚĂǁĞĚƵƉƚŽƚŚĂǁĞĚĂŶĚĨƌŽnjĞŶϭϭƟŵĞƐͿ
ĂƚĂƉƌŽǀŝĚĞĚ͗ĂƚĂƉƌŽǀŝĚĞĚ͗
Age, sex, weight,
height,
BMI, waist
st ccircumference,
irc (race,www.biomedicalspecimenbank.com
ĂƚĂƉƌŽǀŝĚĞĚ͗ Basic anthropometric data (race, sex,
Basic
anthropometric
data
sex, age, height,
sexx, age,
a height,
ϱWŽƐƚƉƌĂŶĚŝĂůWĂŶĞů
ǁĂŝƐƚͲƚŽͲŚŝƉƌĂƟŽ͕ďĂƐŝĐďŝŽĐŚĞŵŝƐƚƌLJ͕ďůŽŽĚĐŽƵŶƚ
weight, BMI), basic biochemistry
weight, BMI), basic biochemistry ƚ
ĂƚĂWƌŽǀŝĚĞĚŽŶZĞƋƵĞƐƚĂƚĞdžƚƌĂŚĂƌŐĞ͗>ĞƉƟŶ͕^ŽůƵďůĞ>ĞƉƟŶ
͕^Ž
ŽůƵ
ϲ^ƚĂƌǀĂƟŽŶWĂŶĞů
ZĞĐĞƉƚŽƌ͕ZĞƐŝƐŝƟŶ͕sĂƐƉŝŶ͕ŚĞŵĞƌŝŶ͕KŵĞŶƟŶ͕Ͳ&W͕ZWͲϰ͕/>ϲ͕
Ͳ&
ϭĚ dĞŵƉĞƌĂƚƵƌĞ^ƚĂďŝůŝƚLJWĂŶĞůĂƚƌŽŽŵƚĞŵƉĞƌĂƚƵƌĞ
ϮĚ dĞŵƉĞƌĂƚƵƌĞ^ƚĂďŝůŝƚLJWĂŶĞůĂƚϯϳΣ
ŵƉĞ
ĞƌĂ
ZW͕W/͕ĞƚĐ͘
(8 healthy individuals, 4 men and 4 women, blood
sera
stored
(8 healthy individuals, 4 men and 4 women, blood donors, urine stored
d donors,
don
ŶLJĂĚĚŝƟŽŶĂůƉĂƌĂŵĞƚĞƌĐĂŶďĞĂĚĚĞĚĂƐĐƵƐƚŽŵĂŶĂůLJƐŝƐͬ
ŵĂŶĂ
ϳdžĞƌĐŝƐĞWĂŶĞů
ĂƚƌŽŽŵƚĞŵƉĞƌĂƚƵƌĞĨŽƌϬƚŽϮϰŚŽƵƌƐ͕ƌĞƐƉĞĐƟǀĞůLJͿ
ĂƚϯϳΣĨŽƌϬƚŽϮϰŚŽƵƌƐ͕ƌĞƐƉĞĐƟǀĞůLJͿ
ĞůLJͿ
ŵĞĂƐƵƌĞŵĞŶƚ͘WůĞĂƐĞŝŶƋƵŝƌĞǁŝƚŚƌĞŐĂƌĚƚŽĂǀĂŝůĂďŝůŝƚLJĂŶĚƉƌŝĐĞ͘
Ăďŝŝdata
ůŝƚ (race, sex, age, height,
ĂƚĂƉƌŽǀŝĚĞĚ͗ Basic anthropometric data (race, sex,
ĂƚĂƉƌŽǀŝĚĞĚ͗ Basic anthropometric
sexx, age,
a height,
weight, BMI), basic biochemistry
weight, BMI), basic biochemistry
ϴtĞĞŬŽĨWƌĞŐŶĂŶĐLJWĂŶĞů
ϮŐĞWĂŶĞů
Our expanding porolio of panels covers both
physiological and pathological condions.
Samples are stored at -150°C, supplied on dry ice
as 0.105 ml serum, urine or other body uid, assorted
in 96 microplate-format boxes.
For more informaon please go to
www.biomedicalspecimenbank.com.
www.biomedicalspecimenbank.com
C
ŝƐĞĂƐĞ^ƚĂƚĞ;WĂƚŚŽůŽŐŝĐĂůͿWĂŶĞůƐ
ϭĞ dĞŵƉĞƌĂƚƵƌĞ^ƚĂďŝůŝƚLJWĂŶĞůĂƚϯϳΣ
ϮĞ
fem
ma of one age)
(384 individuals
of agedĞŵƉĞƌĂƚƵƌĞ^ƚĂďŝůŝƚLJWĂŶĞůĂƚϰΣ
1-90 years, 2 males and 2 females
ϵƐƚƌƵƐͬDĞŶƐƚƌƵĂůLJĐůĞWĂŶĞů
(8 healthy individuals, 4 men and 4 women, blood
sera
stored
(8Age,
healthy
individuals,
4 men
and
4icwomen,
blood donors,
d donors,
don
b
io
ĂƚĂƉƌŽǀŝĚĞĚ͗
sex, weight,
height,
BMI,
basic
biochemistry,
blood urine stored
ĂƚϯϳΣĨŽƌϬƚŽϮϰŚŽƵƌƐ͕ƌĞƐƉĞĐƟǀĞůLJͿ
ĂƚƌŽŽŵƚĞŵƉĞƌĂƚƵƌĞĨŽƌϬƚŽϮϰĚĂLJƐ͕ƌĞƐƉĞĐƟǀĞůLJͿ
count
ϭϬEĞǁďŽƌŶWĂŶĞů
age,
ϭŶĞƌŐLJŵĞƚĂďŽůŝƐŵͬDĞƚĂďŽůŝĐ^LJŶĚƌŽŵĞͬ
ĂƚĂƉƌŽǀŝĚĞĚ͗ Basic anthropometric data (race, sex,
ĂƚĂƉƌŽǀŝĚĞĚ͗ Basic anthropometric
data (race, sex,
height,
sexx, age,
a height,
ŵĂŶĂ
ŶLJĂĚĚŝƟŽŶĂůƉĂƌĂŵĞƚĞƌĐĂŶďĞĂĚĚĞĚĂƐĐƵƐƚŽŵĂŶĂůLJƐŝƐͬ
weight, BMI), basic biochemistry
weight, BMI), basic biochemistry Ăďŝŝůŝƚ
ŵĞĂƐƵƌĞŵĞŶƚ͘WůĞĂƐĞŝŶƋƵŝƌĞǁŝƚŚƌĞŐĂƌĚƚŽĂǀĂŝůĂďŝůŝƚLJĂŶĚƉƌŝĐĞ͘
Obesity
ϭϭƐƐĂLJĞĚ^ĞƌĂWĂŶĞů
ϭĨ dĞŵƉĞƌĂƚƵƌĞ^ƚĂďŝůŝƚLJWĂŶĞůĂƚϰΣ
ϭĂ KďĞƐŝƚLJWĂŶĞů
ϯ^ĞŵŝŶĂůWůĂƐŵĂ
ϯ^ĞdžWĂŶĞů
(8 healthy individuals, 4 men and 4 women, blood
sera stored
d donors,
don
(48 normal healthy males and 48 normal healthy females,
age(96-480
and BMIobese individials)
fem
ma
ĂƚƌŽŽŵƚĞŵƉĞƌĂƚƵƌĞĨŽƌϬƚŽϮϰĚĂLJƐ͕ƌĞƐƉĞĐƟǀĞůLJͿ
ůLJͿ
ĂƚĂƉƌŽǀŝĚĞĚ͗Age, sex, weight, height, BMI, waist circumference,
matched)
ϰĞƌĞďƌŽƐƉŝŶĂů&ůƵŝĚ
ĂƚĂƉƌŽǀŝĚĞĚ͗ Basic anthropometric data (race, sex,
sexx, age,
a height,
ǁĂŝƐƚͲƚŽͲŚŝƉƌĂƟŽ͕ďĂƐŝĐďŝŽĐŚĞŵŝƐƚƌLJ͕ďůŽŽĚĐŽƵŶƚ
ĂƚĂƉƌŽǀŝĚĞĚ͗Age, sex, weight, height, BMI, basic
biochemistry,
blood
ic b
io
weight, BMI), basic biochemistry
ĂƚĂƉƌŽǀŝĚĞĚŽŶƌĞƋƵĞƐƚĂƚĞdžƚƌĂĐŚĂƌŐĞ͗>ĞƉƟŶ͕^ŽůƵďůĞ>ĞƉƟŶ
count
ϱ^LJŶŽǀŝĂůŇƵŝĚ ŵĂŶĂ
ZĞĐĞƉƚŽƌ͕ĚŝƉŽŶĞĐƟŶ͕ZĞƐŝƐƟŶ͕sĂƐƉŝŶ͕ŚĞŵĞƌŝŶ͕KŵĞŶƟŶ͕Ͳ&W͕
ŶLJĂĚĚŝƟŽŶĂůƉĂƌĂŵĞƚĞƌĐĂŶďĞĂĚĚĞĚĂƐĐƵƐƚŽŵĂŶĂůLJƐŝƐͬ
ϭŐ ŝƌĐĂĚŝĂŶWĂŶĞů
ZWͲϰ͕/>ϲ͕ZW͕W/͕ĞƚĐ͘
ŵĞĂƐƵƌĞŵĞŶƚ͘WůĞĂƐĞŝŶƋƵŝƌĞǁŝƚŚƌĞŐĂƌĚƚŽĂǀĂŝůĂďŝůŝƚLJĂŶĚƉƌŝĐĞ͘
Ăďŝůŝƚ
ďŝŝůŝ
(8 healthy individuals, 4 men and 4 women, blood
sera taken
d donors,
don
ŶLJĂĚĚŝƟŽŶĂůƉĂƌĂŵĞƚĞƌĐĂŶďĞĂĚĚĞĚĂƐĐƵƐƚŽŵĂŶĂůLJƐŝƐͬ
A6 Saliva
every hour within 24 hours)
ŵĞĂƐƵƌĞŵĞŶƚ͘WůĞĂƐĞŝŶƋƵŝƌĞǁŝƚŚƌĞŐĂƌĚƚŽĂǀĂŝůĂďŝůŝƚLJĂŶĚƉƌŝĐĞ͘
ĂƚĂƉƌŽǀŝĚĞĚ͗ Basic anthropometric data (race, sex,
sexx, age,
a height,
ϭď DĞƚĂďŽůŝĐ^LJŶĚƌŽŵĞWĂŶĞů
weight, BMI), basic biochemistry
;ϵϲͲϰϴϬŝŶĚŝǀŝĚƵĂůƐǁŚŽŵĞĞƚƚŚĞĚĞĮŶŝƟŽŶĐƌŝƚĞƌŝĂŽĨDĞƚĂďŽůŝĐ
^LJŶĚƌŽŵĞͿ
A1h
,ĞŵŽůLJƟĐͬ>ŝƉĞŵŝĐͬ/ĐƚĞƌŝĐ^ĞƌƵŵWĂŶĞů
ĞŶƚƌĂůŽďĞƐŝƚLJ;ĚĞĮŶĞĚĂƐǁĂŝƐƚĐŝƌĐƵŵĨĞƌĞŶĐĞǁŝƚŚĞƚŚŶŝĐŝƚLJͲƐƉĞĐŝĮĐ
(3 x 32 individuals)
values) and any two of the following:
ĂƚĂƉƌŽǀŝĚĞĚ͗ Basic anthropometric data (race, sex,
sexx, age,
a height,
ͻZĂŝƐĞĚƚƌŝŐůLJĐĞƌŝĚĞƐ͗хϭϱϬŵŐͬĚů;ϭ͘ϳŵŵŽůͬůͿ͕ŽƌƐƉĞĐŝĮĐƚƌĞĂƚŵĞŶƚ
weight, BMI), basic biochemistry
for this lipid abnormality
ͻZĞĚƵĐĞĚ,>ĐŚŽůĞƐƚĞƌŽů͗фϰϬŵŐͬĚů;ϭ͘ϬϯŵŵŽůͬůͿŝŶŵĂůĞƐ͕
фϱϬŵŐͬĚů;ϭ͘ϮϵŵŵŽůͬůͿŝŶĨĞŵĂůĞƐ͕ŽƌƐƉĞĐŝĮĐƚƌĞĂƚŵĞŶƚĨŽƌƚŚŝƐ
lipid abnormality
ͻZĂŝƐĞĚďůŽŽĚƉƌĞƐƐƵƌĞ;WͿ͗ƐLJƐƚŽůŝĐWхϭϯϬŽƌĚŝĂƐƚŽůŝĐW
> 85 mm Hg, or treatment of previously diagnosed hypertension
ͻZĂŝƐĞĚĨĂƐƟŶŐƉůĂƐŵĂŐůƵĐŽƐĞ;&W'Ϳ͗хϭϬϬŵŐͬĚů;ϱ͘ϲŵŵŽůͬůͿ͕
or previously diagnosed type 2 diabetes
ͻ/Ĩ&W'ŝƐхϱ͘ϲŵŵŽůͬůŽƌϭϬϬŵŐͬĚů͕ĂŶŽƌĂůŐůƵĐŽƐĞƚŽůĞƌĂŶĐĞƚĞƐƚŝƐ
ƐƚƌŽŶŐůLJƌĞĐŽŵŵĞŶĚĞĚ͕ďƵƚŝƐŶŽƚŶĞĐĞƐƐĂƌLJƚŽĚĞĮŶĞƉƌĞƐĞŶĐĞŽĨƚŚĞ
syndrome
ͻ/ĨD/ŝƐхϯϬŬŐͬŵϸ͕ĐĞŶƚƌĂůŽďĞƐŝƚLJĐĂŶďĞĂƐƐƵŵĞĚĂŶĚǁĂŝƐƚ
circumference does not need to be measured
ĂƚĂƉƌŽǀŝĚĞĚ͗ Age, sex, weight, height, BMI, waist circumference,
ǁĂŝƐƚͲƚŽͲŚŝƉƌĂƟŽ͕ďĂƐŝĐďŝŽĐŚĞŵŝƐƚƌLJŝŶĐůƵĚŝŶŐĂůůD^ͲƌĞůĂƚĞĚ
ƉĂƌĂŵĞƚĞƌƐ͕ďůŽŽĚƉƌĞƐƐƵƌĞĂƚƐĞƌƵŵĐŽůůĞĐƟŽŶ͕ďůŽŽĚƉƌĞƐƐƵƌĞ
ŵŽŶŝƚŽƌŝŶŐĚĂƚĂͬ,ŽůƚĞƌ;ǁŚĞŶĂǀĂŝůĂďůĞͿ͕ŝŶĨŽƌŵĂƟŽŶĂďŽƵƚ
ĐŽŵŽƌďŝĚŝƟĞƐĂŶĚĐŽƌƌĞƐƉŽŶĚŝŶŐƚŚĞƌĂƉŝĞƐ͕ďůŽŽĚĐŽƵŶƚ
ĂƚĂƉƌŽǀŝĚĞĚŽŶƌĞƋƵĞƐƚĂƚĞdžƚƌĂĐŚĂƌŐĞ͗>ĞƉƟŶ͕^ŽůƵďůĞ>ĞƉƟŶ
ZĞĐĞƉƚŽƌ͕ĚŝƉŽŶĞĐƟŶ͕ZĞƐŝƐƟŶ͕sĂƐƉŝŶ͕ŚĞŵĞƌŝŶ͕KŵĞŶƟŶ͕Ͳ&W͕
ZWͲϰ͕/>ϲ͕ZW͕W/͕/ŶƐƵůŝŶ͕ͲWĞƉƟĚĞ͕,KDͲ/ŶĚĞdž͕,ďϭ͕ZĞŶŝŶ͕
ůĚŽƐƚĞƌŽŶĞ͕ƉŽůŝƉŽƉƌŽƚĞŝŶƐ͕ĞƚĐ͘
ŶLJĂĚĚŝƟŽŶĂůƉĂƌĂŵĞƚĞƌĐĂŶďĞĂĚĚĞĚĂƐĐƵƐƚŽŵĂŶĂůLJƐŝƐͬ
ŵĞĂƐƵƌĞŵĞŶƚ͘WůĞĂƐĞŝŶƋƵŝƌĞǁŝƚŚƌĞŐĂƌĚƚŽĂǀĂŝůĂďŝůŝƚLJĂŶĚƉƌŝĐĞ͘
ϭĚ tĞŝŐŚƚ>ŽƐƐWĂŶĞů
;ϰϴͲϵϲƉĂƟĞŶƚƐƵŶĚĞƌŐŽŝŶŐ^ůĞĞǀĞ'ĂƐƚƌĞĐƚŽŵLJďĞĨŽƌĞĂŶĚŽŶĞǁĞĞŬ͕
ŽŶĞŵŽŶƚŚ͕ƐŝdžŵŽŶƚŚƐĂŶĚĂLJĞĂƌƚŚĞƌĞĂŌĞƌ͕ƌĞƐƉĞĐƟǀĞůLJͿ
ϮŝĂďĞƚĞƐ
Η ͘ ͘ ͘ Ă Ŷ Ě ŵ Ă ŶLJ ŵ Ž ƌ Ğ ƚŽ ĐŽ ŵĞ͊Η
ϯĂƌĚŝŽǀĂƐĐƵůĂƌŝƐĞĂƐĞ
ϭĐ DĞŶƚĂůŶŽƌĞdžLJ;ŶŽƌĞdžŝĂEĞƌǀŽƐĂͿ
(48 normal healthy males and 48 normal healthy females, age and
BMI matched)
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Η ͘ ͘ ͘ Ă Ŷ Ě ŵ Ă ŶLJ ŵ Ž ƌ Ğ ƚŽ ĐŽ ŵ Ğ ͊ Η
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