close

Вход

Log in using OpenID

embedDownload
P RINCESS I MOUKHUEDE , Ph.D.
Assistant Professor, Department of Bioengineering
University of Illinois – Urbana Champaign
1304 W . Springfield Ave., Urbana, IL 61801
217-244-2651 (phone) | 217-265-0246 (fax)
pii@illinois.edu
EDUCATION
Postdoctoral Fellowship, Biomedical Engineering
2008-2011
Johns Hopkins University, School of Medicine, Baltimore, MD
Research Advisor: Aleksander Popel
Quantitatively characterizing and computationally modeling VEGFR in ischemia and cance r.
Ph.D., Bioengineering
2002-2008
California Institute of Technology (Caltech), Pasadena, CA
Research Advisor: Henry Lester
Committee Members: Scott Fraser, Bob Chow, and Changhuei Yang
Applied single-molecule fluorescence, FRET, and TIRF to resolve the structure and trafficking of
the GABA transporter, GAT1.
S.B., Chemical Engineering & Minor in Biomedical Engineering
1998-2002
Massachusetts Institute of Technology (MIT) , Cambridge, MA
Research Advisor: Robert Langer (1998-2001)
Devised experimental strategy for incorporation of adenoviruses & adeno -associated viruses in a
liposome gene therapy system, and created a mathematical model of viral release from the
liposome-viral complex. Introduced a fluorescent marker onto a γ -cyclodextrin based gene delivery
vector. Improved the microencapsulation of an anti-tumor drug using a novel polymer.
Research Advisor: Jean-Francois Hamel (2001)
Assessed growth conditions, viability, and antibody production of hybridoma cells in a novel
TM
bioreactor (W avebioreactor ).
PATENT
Morales, R., Sherin, R.S., Imoukhuede, P.I.U., Burke, D., Gomez, M., Ramirez, D.L., Castaneda,
A. (2003). Construction set for building structures (A63H 033/08 ed, U.S. Pa tent 6,641,453).
United States of America: Academy of Applied Science.
PUBLICATIONS
Roxworthy, B., Johnston, M.T., Lee Montiel, F., Ewoldt, R.H., Imoukhuede, P.I., Toussaint ,K.C.
(2014) Plasmonic Optical Trapping in Biologically Relevant Media. PLoS ONE, 9(4):e93929.
Imoukhuede, P.I., Popel, A.S. (2014) Quantitative fluorescent profiling of VEGFRs reveals
tumor cell and endothelial cell heterogeneity in breast cancer xenografts. Cancer
Medicine, 3(2):225-244.
Lee Montiel, F., Imoukhuede, P.I. (2013) Engineering quantum dot calibration beads for the
profiling of cellular heterogeneity, 1:6434-6441.
Imoukhuede, P.I., Dokun, A.O., Annex, B.H., Popel, A.S. (2013) Hindlimb ischemia induces
temporal changes in VEGFR1 and VEGFR2 levels on endothelial cell expression in mouse
muscle. AJP-Heart and Circulatory Physiology, 304, H1085-H1093.
Imoukhuede, P.I., Popel, A.S. (2012) Expression of VEGF receptors on endothelial cells in mouse
skeletal muscle. PLoS ONE, 7(9): e44791.
P. Imoukhuede CV-2
Imoukhuede, P.I., Popel, A.S. (2011) Quantification and Cell-To-Cell Variation of Vascular
Endothelial Growth Factor Receptors. Experimental Cell Research, 317, 955-965.
Finley, S.D., Engel-Stefanini, M.O., Imoukhuede, P.I., Popel, A.S. (2011) Pharmacokinetics and
pharmacodynamics of VEGF-neutralizing antibodies. BMC Systems Biology, 5:193.
Imoukhuede, P.I., Moss, F.J., Michael, D.J., Chow, R.H, Lester, H.A. (2009) Ezrin mediates
tethering of the gamma-aminobutyric acid transporter GAT1 to actin filaments via a C terminal PDZ-interacting domain. Biophysical Journal, 96, 2949-2960.
Moss, F.J., Imoukhuede, P.I., Jankowski, J.J., Lester, H.A. (2009 ) GABA transporter function,
oligomerization state, and anchoring: correlates with subcellularly resolved FRET. Journal
of General Physiology, 134,489-521.
Moss, F.J., Imoukhuede, P.I., Just, H., Lester, H.A. (2009) GABA Transporters: Structure,
oligomerization, trafficking and pharmacology determine neuronal excitability.
Encyclopedia of Basic Epilepsy Research, 3, 1389-1397.
Drenan, R.M., Nashmi, R., Imoukhuede, P.I., Just, H., McKinney, S., Lester, H.A. (2008).
Subcellular trafficking, pentameric assembly and subunit stoichiometry of neuronal nicotinic
ACh receptors containing fluorescently-labeled α6 and β3 subunits. Molecular
Pharmacology, 73, 27-41.
Crumpler, E., Imoukhuede, P., Keawphalouk, M., Landa, J., Langer, R. (1999). Controlled release
of 9-chloro-2-methylellipticinium acetate from a biodegradable polymer: Release kinetics, in
vitro and in vivo effects on cellular growth. Polymer Preprints, 40, 605-606.
CONFERENCE ABSTRACTS
Weddell, J., Kwack, J., Masud, A., Imoukhuede, P. (2013) Interpreting the effect of heterogeneity
and hemodynamics on tumor angiogenesis using a multi -scale model of anti-angiogenic
therapy. Biomedical Engineering Society National Meeting. Seattle, W A.
Lee Montiel, F.M., Imoukhuede, P.I. (2013) Advancing quantum dot nanosensors and calibration
beads for quantitative cellular profiling. Biomedical Engineering Soc iety National Meeting.
Seattle, W A
Gupta, P.K., Conard, G., Parkin, J., Montiel, F.L., Imoukhuede, P. (2013) Quantitative Flow
Cytometry Analysis of Angiogenic Growth Factor Receptors. Biomedical Engineering
Society National Meeting. Seattle, WA.
Braswell, S, Imoukhuede, P.I. (2013) Linking Mechanobiology & Cellular Heterogeneity in
Angiogenesis. UIUC: Center for Nanoscale Science and Technology W orkshop. Urbana, IL.
Lee Montiel, F.M., Imoukhuede, P.I. (2013) Engineering quantum dot calibration beads fo r the
profiling of cellular heterogeneity. UIUC: Postdoctoral Symposium Beckman Institute.
Urbana IL.
Weddell, J., Kwack, J., Masud, A., Imoukhuede, P. (2013) A Multi -Scale Model of Tumor
Angiogenesis & the Effect of Heterogeneity & Hemodynamics on Anti -Angiogenic Therapy.
Georgia Tech: Frontiers in Systems and Synthetic Biology (FSSB13). Atlanta, GA.
Lee Montiel, F.M., Imoukhuede, P.I. (2013) Engineering Quantum Dot Calibration Beads for the
Profiling of Cellular Heterogeneity. Georgia Tech: Frontiers in Systems and Synthetic
Biology(FSSB13). Atlanta, GA.
Lee Montiel, F.M., Imoukhuede, P.I. (2012) Engineering a multiplex biosensor for the quantification
of cell receptors in mammalian cells. UIUC: Biophotonics Summer School. Urbana, IL.
Lee Montiel, F.M., Imoukhuede, P.I. (2012) Engineering a multiplex biosensor for the quantification
of cell receptors in mammalian cells. UIUC: BioSensing BioActuation BioNanotechnology
P. Imoukhuede CV-3
Summer Institute. Urbana, IL.
Imoukhuede, P.I. (2012) Systems Biology in Angiogenesis. Minority Faculty Development
Workshop. Georgia Institute of Technology. Atlanta, GA.
Imoukhuede, P.I., Popel, A.S. (2011) Quantitative Characterization of Endothelial VEGF Receptors.
NAVBO Workshops in Vascular Biology. Hyannis, MA.
Imoukhuede, P.I., Popel, A.S. (2011) Quantitative Experimental Characterization of Angiogenic
Receptors for Systems Biology. Multiscale Modeling Consortium Systems Biology Meeting.
Bethesda, MD.
Imoukhuede, P.I., Popel, A.S. (2011) Quantifying the basal and pathological surface expression of
VEGFRs on endothelial cells. Gordon Research Conference. Newport, RI.
Imoukhuede, P.I., Popel, A.S. (2009) Determination of vascular endothelial growth factor receptor
balance on human macrovascular and microvascular endothelial cells. National Heart Lung
and Blood Institute Cardiovascular Diversity Research Supplement Awardee Session.
Orlando, FL.
Imoukhuede, P.I., Popel, A.S. (2009) Quantifying the surface density of receptors regulating
angiogenesis. Biomedical Engineering Society Annual Meeting. Pittsburgh, PA.
Imoukhuede, P.I., Popel, A.S. (2009) Endothelial cell surface density of angiogenic receptors.
Merck Research Laboratories. West Point, PA.
Pantoja, R., Srinivasan, R., Moss, F.J., Kadambi, S., Imoukhuede, P.I., Lester, H.A. (2009)
Characterizing nicotine induced α4* nAChR upregulation with fluorescence microscopy.
Biophysical Society National Meeting. Boston, MA.
Imoukhuede, P.I., Moss, F.J., Michael, D.J., Chow, R.H., Lester, H.A. (2008). Ezrin mediates
tethering of the γ-aminobutyric acid transporter GAT1 to actin filaments via a C-terminal
PDZ interacting domain. Merck Research Laboratories. West Point, PA.
Imoukhuede, P.I., Moss, F.J., Michael, D.J., Chow, R.H., Lester, H.A. (2007). Trafficking and
lateral mobility of the γ-aminobutyric acid transporter, GAT1, visualized using FRAP and
TIRF. Biophysical Society National Meeting. Baltimore, MD.
Drenan, R.M., Nashmi, R., Imoukhuede, P., Just, H., Lester, H.A. (2007) Subcellular trafficking,
pentameric assembly and subunit stoichiometry of neuron al nicotinic ACh receptors
containing fluorescently labeled α6 and β3 subunits. Emerging Frontiers in Basic Research
and Clinical Science. San Diego, CA.
Moss, F.J., Imoukhuede, P.I., Jankowsky, J.L., Hu, J., Quick, M., Michael, D.J., Chow, R., Lester,
H.A. (2006) GAT1: Fluorescent constructs reveal motifs for correct transporter trafficking
and dimerization, and reveal its lateral mobility. The GABAergic System. Cold Spring
Harbor, NY.
Imoukhuede, P.I., Moss, F.J., Michael, D.J., Chow, R.H., Lester, H.A. (2006). Quantifying the
dynamics of the γ-aminobutyric acid transporter, GAT1, at the membrane surface and the
GAT1 vesicle with confocal microscopy and total internal refection fluorescence microscopy.
American Society for Cell Biology National Meeting. San Diego, CA.
Moss, F. J., Imoukhuede, P.I., Jankowsky, J.L., Lester, H.A. (2005). Fluorescent mGAT1 constructs
for correct trafficking & dimerization, Society for Neuroscience National Meeting.
Washington, DC.
Imoukhuede, P.I., Moss, F.J., Jankowsky, J.L., Lester, H.A. (2005). Fluorescent mG AT1 constructs
for correct trafficking and dimerization, National Institute of Drug Abuse: Frontiers in
Addiction Research. W ashington, DC: National Institutes of Health.
Imoukhuede, P.I., Moss, F.J., Jankowsky, J.L., Lester, H.A. (2005). Fluorescent mGAT 1 constructs
P. Imoukhuede CV-4
for correct trafficking and dimerization, Kavli Nanoscience Institute Symposium. Pasadena,
CA: Kavli Nanoscience Institute.
Imoukhuede, P.I., Crumpler, E.T., Langer, R. (2000). Oxidation and biotinylation of the 2,3
positions of iodo-γ-cyclodextrin, American Chemical Society National Meeting. San
Francisco, CA: American Chemical Society.
Crumpler, E. T., Venkataraman, G., Imoukhuede, P.I., Langer, R. (2000). Design of tasp-based non
viral delivery vectors: Template assembled porating peptides , American Chemical Society
National Meeting. San Francisco, CA.
Crumpler, E.T., Imoukhuede, P., Kitchens, K., Keawphalouk, M., Landa, J., Langer, R. (1999)
Controlled release of 9-chloro-2-methylellipticinium acetate from a biodegradable polymer:
release kinetics, in vitro, and in vivo effects on cellular growth, American Chemical Society
National Meeting. New Orleans, LA.
FELLOWSHIPS AND GRANTS
American Cancer Society, Illinois Division Basic Research Grant
2013-2014
National Institutes of Health (NCI) Diversity Supplement
2012-2013
FASEB Postdoctoral Professional Development & Enrichment Award
2010-2011
NIH Clinical Research Loan Repayment Program Awardee
2009-2011
UNCF/Merck Postdoctoral Research Fellowship
2008-2010
National Institutes of Health (NHLBI) Postdoctoral Supplement
2008-2010
Kavli Nanoscience Institute Award
National Institutes of Health (NIDA) Predoctoral Supplement
2005
2004-2008
Ford Foundation Graduate Fellowship Honorable Mention
2002
NCAA Postgraduate Scholarship
2002
General Electric Scholarship, Awarded 1of 3 nationwide scholarships.
2001
MIT Undergraduate Research Opportunities Program Fellowship
2000
American Chemical Society Scholar
2001, 2000
Bioengineering Undergraduate Research Award, MIT
1999
Biotechnology Process Engineering Center Research Grant, MIT
1999
Class of 1972 Research Award, MIT
1999
P. Imoukhuede CV-5
AWARDS AND HONORS
Collins Fellow, University of Illinois
2013
National Science Foundation Minority Faculty Development W orkshop, Poster Award
2012
Gordon Conference in Angiogenesis Poster Award
2011
Commitment to Diversity Award, Caltech
2008
Outstanding Service Award, Caltech
2005
CoSIDA-Verizon Academic All-America
2002
Betsy Schumacker Award, MIT
2002
NCAA All-American Indoor Track and Field
2002, 2001
MVP, MIT Varsity Track and Field
2002, 2001
NCAA All-American Outdoor Track and Field
2001
Academic All-American, United States Track Coaches Association
2001
Special Service Award, MIT Department of Chemical Engineering
2001
Visionary Award, MIT National Society of Black Engineers
2001
Torchbearer Award, National Society of Black Engineers
2000-2001
Academic Excellence Award, MIT Office of Minority Education
2000-2002
Multicultural Community Service Award, MIT
2000
OTHER TEACHING EXPERIENCE
Mathematics Adjunct Professor, Howard Community College
Mentor, Caltech Women Mentoring W omen Program
2009
2006-2008
Teaching Assistant, Caltech Biology Course Drugs and the Brain
2006
Research Mentor, Caltech Freshman Summer Institute
2006
Physics and Engineering Curriculum Coordinator and Instructor, Caltech Young
Engineering & Science Scholars Program
2005
Neuroscience Instructor, Caltech Young Engineering & Science Scholars Program.
2004
Physics Facilitator, MIT Seminar XL.
2001
Teaching Assistant, MIT Mechanical Engineering Course.
2001
HTML Instructor, NASA Research in Science and Engineering Program
2000
Research Mentor, MIT Undergraduate Research Opportunities Program.
2000
P. Imoukhuede CV-6
ACADEMIC LEADERSHIP/SERVICE
University of Illinois Faculty W omen of Color in the Academy National Conference,
"Interdisciplinary research" Panelist
2014
University of Illinois, Elizade University Visit, Participant
2014
University of Illinois Heath and Social Justice Committee
2012-
University of Illinois Graduate Mentoring Program, Mentor to 3 graduate students
2012-
University of Illinois, Researchers Initiative, Mentor to 3 undergraduate researchers
2012-
Bioengineering Department, Faculty Search Committee
2012-
Bioengineering Therapeutics Track, Panelist for undergraduate advising seminar
2012-
Bioengineering Department, Graduate Admissions Committee
2012
University of Illinois Cancer Community at Illinois Poster Session Judge
Biomedical Engineering Society (BMES) Annual Meeting, Session C o-chair,
“Biomaterial Topics in Drug Delivery” (Atlanta, GA)
2012
University of Illinois Black Graduate Students Association, “ Navigating the Academy
as a Black W oman” Panelist
2012
University of Illinois Society of Women Engineer, Graduate School Applic ation
“Insider W orkshop,” Panelist
2012
Biophysical Society, Minority Affairs Committee and Reviewer for travel awards
2008-
Caltech, Administrative Committee on Diversity & Minority Affairs
2004-2007
Caltech, SURF/MURF Program Associate
2004, 2006
Caltech, Graduate Review Board
2003-2004
Caltech, Bioengineering Seminar Series Assistant
2002-2003
MIT American Institute of Chemical Engineers, Chapter President,
2001-2002
MIT National Society of Black Engineers, Public Relations Chairperson,
2000-2001
MIT Committee on Multiculturalism, President
1999-2000
New England National Society of Black Engineers, Academic Excellence Chairperson
1999
INVITED LECTURES/SEMINARS
Progress of Women in Science, Technology, Engineering, and Mathematics (STEM);
Administrative Offices of the US Courts; W ashington, DC.
2013
Bimodal Systems Biology: Integrating Biological Assays with Computational Modeling ,
UIUC Institute for Genomic Biology (Urbana, IL)
2013
Systems Biology and Bioengineering: Integrating biologica l assays with computation,
Purdue University Department of Biomedical Engineering (W est Lafayette, IN)
2013
Advancing computational modeling and quantitative receptor profiling of vascular
pathologies, Frontiers in Systems Biology, Georgia Tech (Atlanta, GA)
2013
Systems Biology: VEGF-VEGFR in ischemia and breast cancer, Mayo Clinic (Rochester,
MN)
2012
P. Imoukhuede CV-7
Systems Biology: Angiogenesis in Ischemia and Cancer , UIUC College of
Engineering/VetMed Mini-Symposium (Urbana, IL)
2012
Nanotechnology-mediated sensing of angiogenesis: Quantitative characterization of the
vascular microenvironment, UIUC Center for Nanoscale Science and Technology
Workshop (Urbana, IL)
2012
Systems Biology of Angiogenesis, UIUC Center for Physics of Living Cells Seminar
(Urbana, IL)
2012
Biophysics and Bioengineering, UIUC Molecular Biophysics Training Grant Seminar
(Urbana, IL)
2012
Quantitative Fluorescent Biosensors in Neuroscience, Cardiovascular Disease, and
Cancer, BioSensing BioActuation BioNanotechnology Summer Institute (Ur bana, IL)
2012
Profiling the Vascular Microenvironment: Angiogenic Biosensors & Computational
Modeling, Agricultural and Biological Engineering Seminar (Urbana, IL)
2012
Profiling the Vascular Microenvironment: Quanti tative Fluorescent Biosensors &
th
Computational Modeling, 25 Molecular Biophysics Training Grant Symposium (Urbana, IL)
2012
Profiling the Vascular Microenvironment: Quanti tative Fluorescent Biosensors &
Computational Modeling, Caltech (Pasadena, CA)
2012
Interpreting the vascular microenvironment through quantitative biosensors &
computational modeling University of Michigan Biomedical Engineering Seminar (Ann
Arbor, MI)
2012
Interpreting angiogenesis through systems biology, Institute for Genomic Biology
Regenerative Biology and Tissue Engineering Seminar (Urbana, IL)
2012
Quantification of VEGF Receptor Expression in Hindlimb Skeletal Muscle under Normal
and Ischemic States, Biomedical Engineering Society Annual Meeting, (Hartford, CT)
2011
Quantitative analysis of angiogenic receptors, University of California San Diego (San
Diego, CA)
2010
Quantitative fluorescence reveals novel protein -protein interactions and transporter density
on vesicles, Merck Research Laboratories (Boston, MA)
2008
Trafficking and lateral mobility of the γ -aminobutyric acid transporter, GAT1, visualized
using FRAP and TIRF, Biophysical Society National Meeting, (Baltimore, MD)
2007
GAT1: Fluorescent constructs reveal motifs for correct transporter trafficking &
dimerization & reveal its lateral mobility, Yale University (New Haven, CT)
2007
Dimerization, trafficking & lateral mobility of the  -aminobutyric acid transporter, GAT1,
visualized with FRET, FRAP & TIRF, Johns Hopkins University (Baltimore, MD)
2007
Visualizing the Trafficking and Lateral Mobility of GAT1, California State University Los
Angeles, (Los Angeles, CA)
2006
1/--pages
Пожаловаться на содержимое документа